Fig. 10: Work model of 181-Rik function in the mitochondria-mediated inflammatory response of microglia. | Cell Death & Disease

Fig. 10: Work model of 181-Rik function in the mitochondria-mediated inflammatory response of microglia.

From: A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury

Fig. 10

LncRNA 181-Rik is translated into a 47-AA mitochondrial micropeptide Stmp1, which triggers mitochondrial fission and increases MMP and ROS production. As one possible mechanism, these effects may be exerted through the inhibition of Ucp2 expression by Stmp1. These mitochondrial changes contribute to activating microglia as well as the Nlrp3 inflammasome pathway, which results in microglial pyroptosis and the release of cytokines, eventually leading to RGC death during retinal IR injury. S100a8 and S100a9 appear to function downstream of 181-Rik in the activation of inflammasomes.

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