Fig. 1: In vitro and in vivo response of T1-44. | Cell Death & Disease

Fig. 1: In vitro and in vivo response of T1-44.

From: Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors

Fig. 1

A Dose-dependent inhibition of symmetric arginine di-methylation of SmD3 by T1-44 in Panc02 murine pancreatic cancer cells. B Cell viability of Panc02 by T1-44 measured by MTT assay. Means with SD of OD values were presented relative to control. C Colony formation assay by treatment with various concentrations of T1-44. Colonies were counted after treatment of T1-44 for 2 weeks. D Administration of T1-44 (50 mg/kg, BID) to a subcutaneous tumor model of Panc02 cells. Individual tumor tissue was represented by tumor size for each group (bottom panel). E Graph of tumor volume measured every 3 days. F Tumor weights of vehicle and T1-44 treated groups at endpoint.

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