Fig. 5: Upregulation of Btg2 by Vactosertib and T1-44 combined treatment, suppressing cell migration and promoting apoptosis. | Cell Death & Disease

Fig. 5: Upregulation of Btg2 by Vactosertib and T1-44 combined treatment, suppressing cell migration and promoting apoptosis.

From: Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors

Fig. 5

A FPKM value of Btg2 from RNA sequencing. B qPCR validation using mRNA from combination treated-tumor tissues and C co-treated Panc02 and SNU2491 cell lines. D Relative mRNA expression of BTG2 E Cell migration assay, F Protein markers of EMT response, G apoptosis markers, H flow cytometry analysis of Annexin V, and colony formation assay with overexpressed stable cell lines.

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