Fig. 5: Restoration of BIRC2 expression reverses the inhibitory effect of BRD7 on cell migration and invasion. | Cell Death & Disease

Fig. 5: Restoration of BIRC2 expression reverses the inhibitory effect of BRD7 on cell migration and invasion.

From: BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma

Fig. 5

A Scratch wound healing analysis of cell migration in 5-8 F and HNE1 cells stably with BRD7 overexpression, BRD7 and BIRC2 simultaneous overexpression or control. Quantification of the wound recovery rate of the three groups (right). B Matrigel invasion analysis of cell invasive capabilities in 5-8 F and HNE1 cells stably with BRD7 overexpression, BRD7 and BIRC2 simultaneous overexpression or control. C Significantly differently expressed proteins involved in EMT progression (E-cadherin, N-cadherin, Vimentin, ZO-1) in BRD7 overexpression, BIRC2 overexpression and BIRC2 restoration cells, respectively. GAPDH served as an internal control. Error bars represent the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. All experiments were performed in triplicate.

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