Fig. 6: Dasabuvir attenuates ESCC PDX tumors growth in vivo. | Cell Death & Disease

Fig. 6: Dasabuvir attenuates ESCC PDX tumors growth in vivo.

From: Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1

Fig. 6

A Photographs showed tumors after treated with the vehicle and dasabuvir for EG20 (n = 8), LEG110 (n = 10), LEG34 (n = 7). B Tumor growth curves after treated with the vehicle and dasabuvir for EG20 (n = 8), LEG110 (n = 10), LEG34 (n = 7). C Histograms showed tumor weight after treated with the vehicle and dasabuvir for EG20 (n = 8), LEG110 (n = 10), LEG34 (n = 7). D Line charts of weight change for EG20 (n = 8), LEG110 (n = 10), LEG34 (n = 7). E Ki67 protein levels in ESCC PDX samples were examined by immunohistochemistry (IHC) for EG20 (n = 6), LEG110 (n = 5), LEG34 (n = 6). F p-ERK1/2 protein levels were examined by IHC for EG20 (n = 5), LEG110 (n = 5), LEG34 (n = 5). Scale bar = 50 μm. Data were analyzed by one-way ANOVA test and the asterisk indicated a significant (*p < 0.05, **p < 0.01 and ***p < 0.001) difference compared with the control group.

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