Fig. 7: Loss of UBE2E2 expression inhibits OvCa cell invasion and proliferation in vivo. | Cell Death & Disease

Fig. 7: Loss of UBE2E2 expression inhibits OvCa cell invasion and proliferation in vivo.

From: UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer

Fig. 7: Loss of UBE2E2 expression inhibits OvCa cell invasion and proliferation in vivo.The alternative text for this image may have been generated using AI.

A Illustration of orthotopic implantation of A2780 cells into ovarian bursa. B Fluorescence imaging of the tumor site (radiant efficiency, [p/s/cm2/sr]/[μW/cm2]) (n = 8). C For fluorescence quantification, regions of interest (ROIs) were drawn with Living Imaging 3.0 software, and the total radiant efficiency was determined (*p < 0.05). The expression of the p62, Snail, and E-cadherin proteins in xenograft tumors was explored by (D) western blot and (E) immunohistochemical (IHC) analyses (n = 6, **p < 0.01). The asterisk indicates the protein band of Snail. F Representative IHC images of tumor samples collected from sacrificed mice (×20 magnification, scale bar = 50 μm; ×40 magnification, scale bar = 20 μm).

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