Fig. 5: CEMIP promotes metastasis of CRC cells by bridging GRAF1 and MIB1. | Cell Death & Disease

Fig. 5: CEMIP promotes metastasis of CRC cells by bridging GRAF1 and MIB1.

From: CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway

Fig. 5: CEMIP promotes metastasis of CRC cells by bridging GRAF1 and MIB1.The alternative text for this image may have been generated using AI.

A Transwell chamber migration and invasion of SW480 cells transfected with the indicated constructs. **P < 0.01; ***P < 0.001; ****P < 0.0001. B Representative images of livers of BALB/c nude mice fixed in 10% formaldehyde. Numbers of liver metastases were detected in each group (day 28, n = 5). Representative HE staining of liver tissues was shown. Scale bar, 1 mm. **P < 0.01; ***P < 0.001. C Body weight curves of mice. *P < 0.05; **P < 0.01; ***P < 0.001. D Survival curves of mice. *P < 0.05; **P < 0.01. E Representative immunohistochemical staining for CEMIP, GRAF1 in primary colorectal cancer tissues of BALB/c nude mice mentioned above. The group of GRAF1 were not founded in metastatic foci. Scale bar, 50 μm. F Transwell chamber migration and invasion of SW480 cells transfected with the indicated constructs. ***P < 0.001; ****P < 0.0001.

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