Fig. 6: CEMIP promotes metastasis of CRC cells through GRAF1/CDC42/MAPK pathway-regulated EMT. | Cell Death & Disease

Fig. 6: CEMIP promotes metastasis of CRC cells through GRAF1/CDC42/MAPK pathway-regulated EMT.

From: CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway

Fig. 6: CEMIP promotes metastasis of CRC cells through GRAF1/CDC42/MAPK pathway-regulated EMT.The alternative text for this image may have been generated using AI.

A Western blotting analysis of EMT associated proteins in SW480 cells transfected with the indicated constructs. B Western blotting analysis of EMT associated proteins in SW480 cells transfected with the indicated constructs. C Transwell chamber migration and invasion of SW480 cells transfected with the indicated constructs with or without ZCL278. ***P < 0.001; ****P < 0.0001. D Representative images of livers of BALB/c nude mice, treated with or without ZCL278. Numbers of liver metastases were detected in each group (day 28, n = 5), mice were treated with or without ZCL278. *P < 0.05; **P < 0.01. E Body weight curves of mice treated with or without ZCL278. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. F Survival curves of mice treated with or without ZCL278. *P < 0.05; **P < 0.01.

Back to article page