Fig. 2: Location of IDA components in the human flagellum. | Cell Death & Disease

Fig. 2: Location of IDA components in the human flagellum.

From: DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath

Fig. 2: Location of IDA components in the human flagellum.The alternative text for this image may have been generated using AI.

A A schematic diagram of the positions of the dynein proteins docks on the A-tubule of the microtubule doublet (green) in the 96 nm axonemal repeat, according to the prior structural information on Chlamydomonas and Sea urchin sperm flagella. B–E IF illustrating various dyneins components’ locations on the human sperm flagella. A loss of DNALI1 leads to the mislocation of DNAH1(B) and DNAH7(C). Asterisks indicate the miss of DNAH1 and DNAH7, respectively. F IF staining against DRC1 (a component of the N-DRC structure adjacent to IDA). G The spermatozoa from male infertile patients with indicated protein deficiency are stained with anti-DNALI1.

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