Fig. 4: The roles of SESN2 in inflammatory response.
From: Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases
SESN2 is expressed in immune cells including macrophages, monocytes, and dendritic cells, and architects cellular responses to inflammatory insults. SESN2 when induced by stimuli can exert robust anti-inflammatory function, which is associated with scavenging ROS, promoting autophagy, reducing inflammasome, and diminishing cell death.
