Fig. 3: The Hoxd13 mutation promoted the osteoclast differentiation. | Cell Death & Disease

Fig. 3: The Hoxd13 mutation promoted the osteoclast differentiation.

From: A novel Hoxd13 mutation causes synpolydactyly and promotes osteoclast differentiation by regulating pSmad5/p65/c-Fos/Rank axis

Fig. 3: The Hoxd13 mutation promoted the osteoclast differentiation.The alt text for this image may have been generated using AI.

A The effect of Hoxd13 mutation on the expression of HOXD13 protein. B The effect of Hoxd13 mutation on osteoclast differentiation analyzed using TRAP staining. ***p < 0.001. C The effect of Hoxd13 mutation on the mRNA expression of osteoclast-associated genes. **p < 0.01; ***p < 0.001. D The effect of Hoxd13 mutation on the expression of osteoclast-associated proteins. *p < 0.05; **p < 0.01. All experiments were repeated at least three times.

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