Fig. 1: Several switch events exist in necroptosis. | Cell Death & Disease

Fig. 1: Several switch events exist in necroptosis.

From: The double-edged functions of necroptosis

Fig. 1: Several switch events exist in necroptosis.The alternative text for this image may have been generated using AI.

In TNFR1-induced necroptosis, cells undergo necroptosis only when RIPK1 is deubiquitinated, and caspase-8 is inhibited or absent. All death receptor-induced necroptosis requires the interaction of molecules containing the RHIM domain with the RHIM domain of RIPK3 to activate necroptosis.

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