Fig. 3: TET2/3-STAT1/3-CD274 signaling was upregulated in tumors of mice that responded to anti-PD1 treatment. | Cell Death & Disease

Fig. 3: TET2/3-STAT1/3-CD274 signaling was upregulated in tumors of mice that responded to anti-PD1 treatment.

From: Supplementation with α-ketoglutarate improved the efficacy of anti-PD1 melanoma treatment through epigenetic modulation of PD-L1

Fig. 3: TET2/3-STAT1/3-CD274 signaling was upregulated in tumors of mice that responded to anti-PD1 treatment.

A Plot of Uniform manifold approximation and projection (UMAP) for anti-PD1 treatment profiles (number of tumors from B16F10 tumor-bearing mice: n = 2 and number of tumors from Yumm1.7 tumor-bearing mice: n = 2; n = 21 516 cells), with color coding indicating cell clusters. B Enrichment map of GSEA signaling pathway enriched in Yumm1.7_ anti-PD1 group compared to B16F10_ anti-PD1 group. C–E, Gene expression in Yumm1.7_ anti-PD1 or B16F10_ anti-PD1 single cell clusters.

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