Fig. 1: Depletion of Setdb1 activates necroptosis and a large number of of TEs. | Cell Death & Disease

Fig. 1: Depletion of Setdb1 activates necroptosis and a large number of of TEs.

From: Transposable elements activation triggers necroptosis in mouse embryonic stem cells

Fig. 1

A Western blot analysis of the necroptotic markers such as phosphorylation RIP3, phosphorylation RIP, phosphorylation MLKL and pluripotent markers such as NANOG and OCT4 in Setdb1 cKO cell with/without 4OHT treatment. B Volcano plots of up-regulated and down-regulated genes and TEs after Setdb1 knockout in 2iL condition. C Pie chart of the up-regulated/down-regulated genes nearby TEs (5 kb). Overlap score range from 0 to 1.

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