Fig. 7: Schematic illustration of the hypothesized mechanism of Sal’s effect on ferroptosis.
From: PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma
Sal exhibits pro-ferroptic effect in RCC via downregulating PDIA4. Administration of Sal stimulates autophagic degradation and thus inhibits PDIA4. Downregulation of PDIA4 suppresses ATF4 and SLC7A11, thereby inactivates GPX4 and promotes ferroptosis.
