Fig. 1: GEMC1 and MCIDAS overexpression activates overlapping and distinct target genes. | Cell Death & Disease

Fig. 1: GEMC1 and MCIDAS overexpression activates overlapping and distinct target genes.

From: GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program

Fig. 1

A Volcano plots (-Log10 p-value vs Log2 fold change) of microarray analysis of gene expression following transient transfection of GEMC1 and B MCIDAS in AD-293 cells (n = 2 biological replicates). Genes in the Cilium and Transcription Factor Binding GO-SLIM categories (TFB = Transcription factor binding), genes implicated specifically in multiciliated cells or genes enriched with MCIDAS over GEMC1 are indicated by color (legend in A, applies to A-D). Full details in Supplementary Tables S2 and S3. C Heatmap comparing expression (Log2 fold change = Log2FC) of most upregulated genes following either GEMC1 or MCIDAS expression. Color coding of gene categories is applied as in A. D Gene set enrichment analysis of the gene expression data using GO-SLIM categories. The nominal enrichment score (NES) for each category with either GEMC1 or MCIDAS is shown. Details in Supplementary Table S3.

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