Table 2 Important N-glycosylation events in liver cancer.
From: The role of N-glycosylation modification in the pathogenesis of liver cancer
Protein | N-glycosylation events in liver cancer | Outcome/Application |
|---|---|---|
E-Cadherin | Reduce bisecting N-glycan structure | The interaction between E-Cadherin and β-catenin is weakened, and β-catenin enters the nucleus to activate the Wnt signaling pathway and promote the EMT process |
CD44 | Increase sialylation levels | Promote the intercellular adhesion |
Integrin | Raise sialylation and core fucosylation levels | Inhibit the proliferation of liver cancer cells |
Fibronectin | Elevate sialylation levels | Influence its interaction with integrins, altering cell adhesion |
Laminin | Increase the formation of β1, 6-branch | Enhance intercellular adhesion. |
AFP | Expand core fucosylation levels | More reliable clinical diagnostic and prognostic indicator of liver cancer |
AGP | Raise sialylation levels | Increase diagnostic accuracy of liver cancer |
Haptoglobin | Widen sialylation levels, lessen the formation of N-glycan branching structure | Reduce false negative results of diagnosis |
N-Acetylneuraminic acid 
N-Acetylglucosamine 
Mannose 
Galactose
N-Acetylneuraminic acid 
N-Acetylglucosamine 
Mannose 
Galactose