Fig. 8: Schematic representation of the potential intracellular role of IgG2B to preservation and conversion of the astrocyte phenotype. | Cell Death & Disease

Fig. 8: Schematic representation of the potential intracellular role of IgG2B to preservation and conversion of the astrocyte phenotype.

From: Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion

Fig. 8

IgG2B can interact either with proteins from the endoplasmic reticulum, with LAT1 or integrins at the membrane surface. The blue pathway is found upon CRISPR-Cas9 invalidation of the IgG2B heavy chain while the orange pathway was identified upon overexpression. The proteins in red were demonstrated in proximal interaction with IgG2B. The ones in gray are related to proteins involved in ILKAP and CD98hc/LAT1/SLC7A5 signaling pathway.

Back to article page