Fig. 4: GPAT3 deletion prevents LPS-induced hepatic injury and primary KCs inflammatory response. | Cell Death & Disease

Fig. 4: GPAT3 deletion prevents LPS-induced hepatic injury and primary KCs inflammatory response.

From: GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway

Fig. 4: GPAT3 deletion prevents LPS-induced hepatic injury and primary KCs inflammatory response.The alternative text for this image may have been generated using AI.

A Experimental design of LPS-induced inflammation model using GPAT3+/+ and GPAT3-/- mice. B Plasma ALT, AST and LDH concentration of mice (n = 6). C Plasma IL-1β and IL-6 production of mice (n = 6). D Representative images of HE staining (Scale bars represent 200 μm) in liver of mice (n = 3). E The mRNA levels of IL-1α, IL-6 and MCP-1 in primary KCs (n = 3). F Mitochondrial membrane potential in primary KCs (n = 3). Data represents mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.

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