Fig. 6: KRT7-AS increases the levels of oncogenic KRT7 in lung cancer and breast cancer. | Cell Death & Disease

Fig. 6: KRT7-AS increases the levels of oncogenic KRT7 in lung cancer and breast cancer.

From: The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers

Fig. 6: KRT7-AS increases the levels of oncogenic KRT7 in lung cancer and breast cancer.The alternative text for this image may have been generated using AI.

The relationship between KRT7 and KRT7-AS in genomic DNA is depictured in (A). KRT7 protein levels in lung cancer (B) and breast cancer (C) were detected by Western blotting. The levels of KRT7 protein in the lung cancer (D, E) and breast cancer (F, G) tissues and in the paired normal tissues were examined by IHC. Expression levels of KRT7 downstream FOXA1 gene in lung cancer (H) and breast cancer (I) were detected using real time qPCR. Western blotting showed that KRT7 protein was decreased in KRT7-AS-overexpressed SPC-A-1 and H1299 lung cancer cells (J, K). In KRT7-ASoverexpressed MCF-7 cells, KRT7 protein levels were reduced (L, M). Data are shown as mean ± SD of three independent replicates. **P < 0.01.

Back to article page