Fig. 1: TXNIP is downregulated by BCR-ABL transformation. | Cell Death & Disease

Fig. 1: TXNIP is downregulated by BCR-ABL transformation.

From: BCR-ABL triggers a glucose-dependent survival program during leukemogenesis through the suppression of TXNIP

Fig. 1

A Volcano plot representing the genes significantly differentially expressed in K562 and K562G (P < 0.05). B Relative mRNA levels of TXNIP in the PB and BM were compared among samples from normal healthy donors and patients as described in the figure. Each individual dot represents 1 sample. CP, chronic phase; AP, accelerated phase; BP, blast phase. C, D TXNIP protein (C) and mRNA (D) levels after BCR-ABL transduction (MIG210) in normal CD34+ cells from 2 independent healthy donors. Empty vector MIGR1 was used as a control. E, F TXNIP protein (E) and mRNA (F) levels in indicated CML cells 24 h after 0.5 μM imatinib treatment. G, H TXNIP protein (G) and mRNA (H) levels in K562 and K562G cells 24 h after 0.5 μM imatinib treatment. I TXNIP protein levels in K562 and KCL22 cells after BCR-ABL knockdown by shABL lentiviral vector. ***P < 0.001. **P < 0.01.

Back to article page