Fig. 4: Pathological evidence of LUAD patients. | Cell Death & Disease

Fig. 4: Pathological evidence of LUAD patients.

From: Identification of RAC1 in promoting brain metastasis of lung adenocarcinoma using single-cell transcriptome sequencing

Fig. 4

a, b Compared with normal tissue, expression level of RAC1 (IOD, Integrated Optical Density) increased significantly in LUAD tissues, based on HPA database (normal tissue, n = 3; LUAD, n = 3; Fold change = 2.63; P < 0.01). c, d Additional tissue samples from 6 patients with both primary and metastatic LUAD were used for RAC1 staining analysis. IOD results showed high expression of RAC1 in the metastases (normal tissue, n = 6; LUAD, n = 6; Fold change = 3.83; P < 0.05). e Survival analyses of RAC1 expression in LUAD patients. The red line represents patients with higher RAC1 and the blue line denotes patients with lower RAC1 expression. The survival time of LUAD patients with high RAC1 expression was lower (red line) with median survival of 1081 days, compared to a more favorable survival of patients with low RAC1 expression (1798 days, P = 0.0015).

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