Fig. 7: Animal experiment. | Cell Death & Disease

Fig. 7: Animal experiment.

From: Identification of RAC1 in promoting brain metastasis of lung adenocarcinoma using single-cell transcriptome sequencing

Fig. 7

a The MRI T2WI sequences of the Blank and NC groups did not show high signal shadows in the brain parenchyma. The MRI T2WI sequences of the RAC1-OE group showed high signal shadows in the brain parenchyma, indicating that the lung cancer cells metastasized to the brain. b The primary focal tumor was significantly heavier in the RAC1-OE group than in the NC group (P < 0.001). c qPCR results showed that RAC1 overexpression H1975 cells were successfully constructed (P < 0.001). d HE and Pan-CK staining results demonstrated the presence of metastatic foci in the brain of the RAC1-OE group. e RT-PCR on brain tissue showed the expression of RAC1, CDK4, CDK6, and CyclinD1 was significantly increased in the RAC1-OE group. Data are expressed as means ± SD; *P < 0.05, **P < 0.01, ***P < 0.001.

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