Fig. 6: NKTL lacks BAX expression, which leads to the inability to induce mitochondrial cyt-C released apoptosis. | Cell Death & Disease

Fig. 6: NKTL lacks BAX expression, which leads to the inability to induce mitochondrial cyt-C released apoptosis.

From: Inhibition of extranodal NK/T-cell lymphoma by Chiauranib through an AIF-dependent pathway and its synergy with L-asparaginase

Fig. 6

A Immunoblotting analysis of Bax expression in different types of lymphoma cell lines. B, C Immunohistochemistry assay of Bax expression in human NKTL, DLBCL, and PTCL tissue (shown in red arrow). n for independent patient number. D Immunoblotting analysis of caspase pathway in Bax overexpressed SNK6 cells treated with Chiauranib or DMSO. Bax overexpression is shown in Supplementary Fig. 1C. E Immunoblotting analysis of mitochondria and cytosol enriched fractions of SNK6 cells after Bax overexpression.

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