Fig. 3: Tumor NOS2/COX2 and CD8+ T cells occupy unique areas in the tumor microenvironment. | Cell Death & Disease

Fig. 3: Tumor NOS2/COX2 and CD8+ T cells occupy unique areas in the tumor microenvironment.

From: Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome

Fig. 3

A Multiplex fluorescence of an ER-/HER2 + breast tumor showing NOS2 (red), COX2 (green), CKSOX10 (blue), CD8+ T cells (magenta), and DAPI (white). B Spatial distribution (left) and density heat maps (right) of NOS2, COX2, or CD8+ T cells. Spatial distributions reflect a positive detection of the markers within 25 µm diameter areas independent of amount. Density heat maps provide a visual quantitation reflected by color gradation (low-high) blue, green, yellow, orange, and red of the biomarker protein expressions. C comparison of NOS2/CD8, COX2/CD8, and NOS2/COX2 spatial distribution combinations.

Back to article page