Fig. 8: Potential mechanism by which Cis exacerbates ovarian GCs death.
From: Chemotherapy impairs ovarian function through excessive ROS-induced ferroptosis
Exposed to Cis leads to ovarian GCs ferroptosis and apoptosis. Cis induces mitochondrial dysfunction and downregulates the expression of GPX4 in ovarian GCs, leading to excessive ROS production and upregulation of apoptosis-related factors. The excessive intracellular ROS combines with Fe2+ to initiate the Fenton reaction, thereby inducing cell ferroptosis. NAC rescues Cis-induced cell death by reducing excessive ROS levels and enhancing antioxidant capacity.
