Fig. 7: A small molecule SHP-1 agonist, SC-43 exerts an anti-pulmonary fibrosis activity by targeting macrophages. | Cell Death & Disease

Fig. 7: A small molecule SHP-1 agonist, SC-43 exerts an anti-pulmonary fibrosis activity by targeting macrophages.

From: Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis

Fig. 7

A The abundances of macrophages were visualized in tSNE maps, color-coded by cell density (yellow for high density, purple for low density). The number indicates the cluster ID of each FlowSOM metacluster. B The expression levels of the indicated markers visualized in tSNE maps. C Heatmap of median arcsinh-transformed intensities of indicated markers in each metacluster. D Fibrotic gene expression in BALF cells were detected using RT-qPCR. Results were normalized to IPF mice with vehicle and represented as mean ± SD of three mice in triplicates. The data were analyzed by two-way ANOVA with a Dunnett’s post hoc test. (**p < 0.01; ***p < 0.001). E This schematic diagram provides a brief overview showing that SC-43, via CSF1R downregulation, suppresses the survival and M2 polarization of macrophages, leading to the inhibition of fibroblast-to-myofibroblast transition and the alleviation of pulmonary fibrosis.

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