Fig. 1: The expression of PDE4DIP is upregulated in human CRC tissues and associated with poor survival of patients. | Cell Death & Disease

Fig. 1: The expression of PDE4DIP is upregulated in human CRC tissues and associated with poor survival of patients.

From: PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis

Fig. 1: The expression of PDE4DIP is upregulated in human CRC tissues and associated with poor survival of patients.The alternative text for this image may have been generated using AI.

A qRT‒PCR analysis of PDE4DIP mRNA levels in human CRC tumors. PDE4DIP mRNA expression in 60 paired CRC tumors and adjacent normal mucosa was assessed by qRT‒PCR. B Immunohistochemical staining of the PDE4DIP protein in CRC specimens (T) and paired adjacent normal intestine samples (N). Scale bar, 50 μm. C Western blot showing the protein levels of PDE4DIP in CRC samples (T) and adjacent normal tissues (N) from eight patients. D Kaplan‒Meier survival analysis of CRC patients with PDE4DIP-high vs. PDE4DIP-low tumors from the TCGA cohort. Normalized TCGA data were downloaded from cBioPortal (http://www.cbioportal.org/, colorectal adenocarcinoma, PanCancer Atlas), and PDE4DIP mRNA expression levels in patients with colon adenocarcinoma were used for Kaplan‒Meier survival analysis. E Kaplan‒Meier analysis of relapse-free survival in CRC patients with PDE4DIP-high vs. PDE4DIP-low tumors from the GSE14333 cohort. F Kaplan‒Meier analysis of relapse-free survival in CRC patients from a combined cohort comprising GSE14333, GSE17536, and GSE17537. All Kaplan‒Meier curves were generated by the R2 program (https://hgserver1.amc.nl/cgi-bin/r2/main.cgi).

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