Fig. 8: RNF128 overexpression reduces LPS-induced lung injury.
From: RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury
A, B The mice were administered with LPS (i.t.) for 24 h. Histological images of lung tissues stained with haematoxylin and eosin (HE) in the indicated groups. Scale bars: 100 μm. An experienced pathologist assigned severity scores to lung injuries. The total cells (C), monocytes (D) and PMN (E) in the BALF were derived from LPS-stimulated AAV9-Vector and AAV9-RNF128 mice. F The protein levels of MPO, TLR4 and RNF128 in the lungs of AAV9-Vector and AAV9-RNF128 mice treated with LPS were detected using immunoblotting. G MPO activity was determined in the lung tissues from the indicated groups. H The working model of RNF128 in the regulation of LPS-induced ALI. The data are presented as mean ± standard deviation (SD). The statistical significance was evaluated using one-way ANOVA with Newman–Keuls post hoc test or Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.001.
