Fig. 6: Inhibition of NK1R blocks the growth of ENZ-resistant and NE-like CRPC in vitro and vivo. | Cell Death & Disease

Fig. 6: Inhibition of NK1R blocks the growth of ENZ-resistant and NE-like CRPC in vitro and vivo.

From: Neurokinin-1 receptor drives PKCɑ-AURKA/N-Myc signaling to facilitate the neuroendocrine progression of prostate cancer

Fig. 6

A IC50 values of aprepitant and enzalutamide in various prostate cancer cell lines. B Western blot assay of shRNA-mediated NK1R knockdown in 22Rv1-NE and LNCaP-NE cells. The effect of NK1R knockdown on C cell growth curve, D colony formation, and E transwell cell migration. Colonies and the infiltrated cells were calculated by Image J. F IHC analysis of N-myc, p-AURKA, p-ERK, p-AKT, Ki67, and Caspase3 in tumor xenografts. Scar bar, 50 μm. Data were shown by mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001.

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