Fig. 1: Trib1 expression was downregulated during the early phase of liver regeneration.
From: TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response
A–C C57B6/L mice were subjected to partial hepatectomy (2/3 PHx) and sacrificed at indicated time points. Trib1 expression was examined by qPCR, western blotting, and immunohistochemical staining. N = 5 mice for each group. D–F C57B6/L mice were injected with acetaminophen (APAP, 300 mg/kg) and sacrificed at indicated time points. Trib1 expression was examined by qPCR, western blotting, and immunohistochemical staining. N = 5 mice for each group. G, H Primary murine hepatocytes were treated with HGF and harvested at indicated time points. Trib1 expression was examined by qPCR and western blotting. N = 3 biological replicates. Data are expressed as mean ± S.D. *p < 0.05, one-way ANOVA with post-hoc Scheff´e.
