Fig. 6: Model of OTUDin3 inhibits NSCLC through targeting deubiquitylase OTUD3.
From: Discovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer
OTUDin3 inhibits the deubiquitinating activity of OTUD3, resulting in enhanced ubiquitination of GRP78 and a consequent decrease in GRP78 protein levels, thereby inducing apoptosis of NSCLC cells. By Figdraw.
