Fig. 1: Mitochondrial TIMM13 upregulation in OS tissues and cells.
From: HOXC13-driven TIMM13 overexpression promotes osteosarcoma cell growth
Expression of listed mRNAs (A) and proteins (B) in the described OS tissues (“O”) and the fragmented bone tissues (“B”) removed from fracture surgeries of age and gender-matched healthy donors was shown, with results quantified. TCGA database shows the Kaplan–Meier survival results of TIMM13-high sarcoma patients and TIMM13-low sarcoma patients (C). Expression of TIMM13 mRNA and TIMM13 protein (in both mitochondria lysates and mitochondria-null lysates) in primary human OS cells (pOS-1 and pOS-2), primary human osteoblasts (“pOb”) and hFOB1.19 osteoblasts were shown (D, E). Error bars stand for mean ± standard deviation (SD). *P < 0.05 versus “B” tissues/“pOb” cells.
