Fig. 7: HOXC13-dependent TIMM13 transcription is increased in OS tissues and cells.
From: HOXC13-driven TIMM13 overexpression promotes osteosarcoma cell growth
The primary pOS-1 cells expressing the HOXC13 shRNA (“sh HOXC13-S1”/“shHOXC13-S2”, with different sequences), the scramble control shRNA (“shC”), the TIMM13-expressing construct (“HOXC13-OE”) or the empty vector (“Vec”), were established, and expression of listed genes and proteins were shown (A–F). Chromosome IP (ChIP) results showed the relative levels of HOXC13-bound TIMM13 promoter in the listed human OS tumor tissues and pare-tumor normal bone tissues (G), as well as in the listed OS cells and osteoblasts (H). “Pare” stands for the parental control of OS cells. Error bars stand for mean ± standard deviation (SD, n = 5). * P < 0.05 vs. “Pare”/“shC” cells. Experiments in this figure were repeated five times.
