Fig. 2: Deficiency of hepatocyte DDX3X exacerbate APAP induced DILI in mice. | Cell Death & Disease

Fig. 2: Deficiency of hepatocyte DDX3X exacerbate APAP induced DILI in mice.

From: Hepatocyte DDX3X protects against drug-induced acute liver injury via controlling stress granule formation and oxidative stress

Fig. 2: Deficiency of hepatocyte DDX3X exacerbate APAP induced DILI in mice.

A Schematic diagram of APAP induced DILI model; B, C mRNA and protein expression of DDX3X in mice treated with PBS or APAP for 12 h. n = 3/group; D Histological evaluation of liver sections from DDX3Xfl/fl and DDX3XΔhep mice treated with APAP or PBS for 12 h, respectively. Scale bars, 100 µm (top), 20 µm (bottom). n = 6/group; E Serum levels of ALT and AST of DDX3Xfl/fl and DDX3XΔhep mice with APAP induction. n = 6/group; F Survival assay of DDX3Xfl/fl and DDX3XΔhep mice treated with APAP or PBS for 72 h, respectively. n = 10/group. Data are expressed as mean ± SD. **p < 0.01.

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