Fig. 7: The USP11/LSH/CYP24A1 axis is aberrantly activated in CRC. | Cell Death & Disease

Fig. 7: The USP11/LSH/CYP24A1 axis is aberrantly activated in CRC.

From: USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1

Fig. 7

A Immunohistochemical analysis of USP11, LSH, and CYP24A1 expression in human CRC and adjacent normal tissues. Scale bar, 50 μm. B Correlations between USP11 and LSH and between LSH and CYP24A1 were analyzed by Linear regression analysis (n = 94). C Analysis of CRC patient prognosis stratified by USP11, LSH, and CYP24A1 expression levels. D Tumor formation in the xenografted mice (n = 6 per group) (left). WB analysis of the indicated proteins (right). E Tumor growth rate of xenografts in BALB/c nude mice. Tumor weight and volumes were measured and plotted. Values are presented as mean ± SD (n = 6). F Immunohistochemical analysis of tumor xenografts. Scale bar, 50 μm. G Schematic model of USP11/LSH/CYP24A1 axis-mediated resistance to ferroptosis in CRC cells.

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