Fig. 4: BH3 mimetics sensitize OVCAR 5 cells to olaparib.
From: Bcl-2 family inhibitors sensitize human cancer models to therapy
Heat map graphs showing A cell growth inhibitory effect and B Loewe scores of cells treated with the indicated concentrations of IS21 and olaparib alone or in combination for 5 days. C Representative images (upper panel) and relative quantification (lower panel) of colony assay of cells treated for 10 days with olaparib (1.25 μM) and IS21 (10 μM) alone or in combination. Results represent the mean ± SD of three independent experiments. p-values were calculated between cells treated in combination and those treated with single agents, *p < 0.05, **p < 0.01. Heat map graphs showing D growth inhibitory effect and E Loewe scores of cells treated with the indicated concentrations of ABT-199 and olaparib alone or in combination for 5 days. A, D The results are reported as inhibition of treated cells/inhibition of control cells × 100, and as mean of three independent experiments. A, B, D, E The numbers inside the squares indicate values in every experimental point.
