Fig. 4: Increased secondary neurodegeneration was associated with neuroinflammation in tricultures 24 hours after injury. | Cell Death & Disease

Fig. 4: Increased secondary neurodegeneration was associated with neuroinflammation in tricultures 24 hours after injury.

From: Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model

Fig. 4

Human Neuro Discovery Array of inflammatory markers: IL-1α, IL-1β, TNFα, CNTF, IL6, IL8, IFNγ, and Fas ligand; Neurotrophic and Growth factors: BDNF, GDNF, GM-CSF; Pro-regenerative marker: IL-4; Extracellular matrix remodeling proteins: MMP2, MMP3, LIF, and TIMP1 secreted 24 h after injury in triculture NAM cultures with/-out P110 treatment. Data normalized to sham without drug treatment. Data presented are the mean ± SEM of four independent experiments, with each data point being the average for n = 4 scaffolds per condition. *, **, *** indicate significant differences (p < 0.05, 0.01, 0.001, respectively; two-way ANOVA (with Tukey’s post hoc test) between control and experimental groups).

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