Fig. 4: MiR-150 decreases cardiac fibrosis post-myocardial infarction in part by repressing Sprr1a. | Cell Death & Disease

Fig. 4: MiR-150 decreases cardiac fibrosis post-myocardial infarction in part by repressing Sprr1a.

From: SPRR1A is a key downstream effector of MiR-150 during both maladaptive cardiac remodeling in mice and human cardiac fibroblast activation

Fig. 4

Representative Masson’s trichrome staining (A, B) in heart sections of the peri-ischemic border area in the 6 experimental groups at 8 weeks post-MI and fibrosis quantification (C) in whole left ventricles (LVs). Fibrosis histology images from whole heart longitudinal sections (A: Scale bars: 1 mm) and zoomed in images of the peri-ischemic border area (B: Scale bars: 100 μm). N = 6 per group. Two-way ANOVA with Tukey’s multiple comparison test. ***P < 0.001 vs. sham for each genotype; #P < 0.05 or ##P < 0.01 vs. WT or miR-150 KO. Data are presented as the mean ± SEM.

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