Fig. 6: ZIC2 and JUNB are elevated in NPC tissue and are associated with a poor prognosis in NPC patients. | Cell Death & Disease

Fig. 6: ZIC2 and JUNB are elevated in NPC tissue and are associated with a poor prognosis in NPC patients.

From: ZIC2 induces pro-tumor macrophage polarization in nasopharyngeal carcinoma by activating the JUNB/MCSF axis

Fig. 6: ZIC2 and JUNB are elevated in NPC tissue and are associated with a poor prognosis in NPC patients.

A The expression levels of ZIC2 and JUNB in NPC tissues and unpaired nontumorous nasopharyngeal tissues were detected by RT-PCR, and β-actin served as an internal control. B Positive correlations were found between the expression of ZIC2 and JUNB in nasopharyngeal carcinoma. The statistical analysis was performed using Spearman’s correlation analysis and linear regression. C Representative images of immunohistochemical staining for ZIC2 and JUNB in NPC. D–F Overall survival curves of NPC patients with low and high expression of ZIC2 (D), JUNB (E), or CD163 (F) by Kaplan–Meier survival analysis (p = 0.008, p = 0.046, p = 0.031). G Overall survival curves of NPC patients with low and high expression of ZIC2 and JUNB (p = 0.012). H Overall survival curves of NPC patients with low and high expression of ZIC2 and CD163 (p = 0.003). I Overall survival curves of NPC patients with low and high expression of ZIC2, JUNB, and CD163 (p = 0.010).

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