Fig. 1: LPS/D-Gal-induced upregulation of hepatic IRG1. | Cell Death & Disease

Fig. 1: LPS/D-Gal-induced upregulation of hepatic IRG1.

From: Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury

Fig. 1

A, B The expression profiling data from the NCBI GEO database (GSE190823) was analyzed. A Volcano plots showing the DEGs (P-value < 0.05 and |log2 fold change (FC)| > 1) between LPS/D-Gal-insulted liver and normal control liver. B The most highly upregulated 20 genes were shown. C–E Mice with LPS/D-Gal-induced fulminant liver injury were sacrificed at the indicated time points. The levels of C IRG1 mRNA and D IRG1 protein were determined (n = 4). E Non-parenchymal cells (NP) and hepatocytes (HEP) were separated from the liver samples collected 6 h post LPS/D-Gal exposure, and the levels of IRG1 protein in NP and HEP were determined (n = 4). All data were expressed as mean ± SD.

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