Fig. 6: Nrf2 pathway and oxidative stress were associated with IRG1/itaconate in fulminant liver injury. | Cell Death & Disease

Fig. 6: Nrf2 pathway and oxidative stress were associated with IRG1/itaconate in fulminant liver injury.

From: Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury

Fig. 6

A, B WT or IRG1 KO mice with fulminant liver injury were sacrificed 6 h post LPS/D-Gal exposure. A The hepatic contents of TBARS, the GSSG/GSH ratio in the liver, and the serum level of 8-OH-dG were determined (n = 8). B The protein levels of Nrf2, HO-1, and NQO1 in liver samples were determined (n = 4). C, D WT or IRG1 KO mice with fulminant liver injury were supplemented with 4-octyl itaconate (4-OI) and sacrificed 6 h post LPS/D-Gal exposure. C The hepatic contents of TBARS, GSSG/GSH ratio in the liver, and the serum level of 8-OH-dG were determined (n = 8). D The protein levels of Nrf2, HO-1, and NQO1 in liver samples were determined (n = 4). All data were expressed as mean ± SD.

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