Fig. 6: LEF1 and KDM4A promote the growth of oral squamous tumour xenografts. | Cell Death & Disease

Fig. 6: LEF1 and KDM4A promote the growth of oral squamous tumour xenografts.

From: Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1

Fig. 6

Knockdown efficiency of shRNAs targeting LEF1 or KDM4A. B CAL-27 cells infected with lentiviruses carrying the indicated shRNAs were inoculated subcutaneously into the 6-week-old male NOD/SCID mice (n = 4). Primary tumours were quantified through bioluminescence imaging at 4 weeks after initial implantation. Representative in vivo bioluminescence images are shown, and tumour specimens were examined using in vitro bioluminescence measurements. C Tumour specimens were examined by in vitro measurements. D WB was used to verify the efficiency of protein knockdown and the expression of LATS2 in tumours. Data represent the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.

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