Fig. 5: Anti-CRC activities of FDW028. | Cell Death & Disease

Fig. 5: Anti-CRC activities of FDW028.

From: FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer

Fig. 5

A The colony formation abilities of SW480 and HCT-8 cells treated with FDW028 at 50 μM for 14 days. B The viabilities of SW480 and HCT-8 cells upon the treatment of FDW028 at the indicated concentrations for 72 h, with or without FUT8 knockdown. Transwell assays (C) and wound-healing assays (D) for showing the migration abilities of SW480 and HCT-8 cells treated with FDW028 at 50 μM for 72 h. E Growth curves and photos of SW480 xenografts treated with FDW028 (10 or 20 mg/kg) or 5-Fu (10 mg/kg). F The body weights of tumor-bearing mice with the administration of FDW028 or 5-Fu. G The survival of CRPM mice after i.v. injection of FDW028 at 20 mg/kg once the other day. HE stains of the lung of normal and tumor-bearing mice are shown. i.v. intravenously; t.a. tumor-aside; *P < 0.05, **P < 0.01, ***P < 0.001.

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