Fig. 7: Schematic diagram showing the pharmacological mechanism of FDW028. | Cell Death & Disease

Fig. 7: Schematic diagram showing the pharmacological mechanism of FDW028.

From: FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer

Fig. 7: Schematic diagram showing the pharmacological mechanism of FDW028.The alternative text for this image may have been generated using AI.

FDW028, an inhibitor specifically targeted FUT8, promotes defucosylation and consequent HSC70/LAMP2A-mediated lysosomal degradation of B7-H3, and exhibits potent anti-mCRC activities.

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