Fig. 12: Proteomic analyses to evaluate the effect exerted by Heimdall neutralization and Isotype treatment on DI TNC1 astrocytes cell line.

Heatmap representing the variation in the abundance of proteins identified after treatment with anti-Heimdall or isotype control antibody (n = 3). Two specific clusters were observed. Proteins identified in Cluster 1 were linked to the neuroinflammation and neural development. Proteins identified in Cluster 2 were involved in pluripotency, notch pathway, differentiation and development, neuronal progenitor and RUNX3 expression.