Fig. 3: Mitochondria OXPHOS pathway and TCA cycle participate in the ferroptosis. | Cell Death & Disease

Fig. 3: Mitochondria OXPHOS pathway and TCA cycle participate in the ferroptosis.

From: The diversified role of mitochondria in ferroptosis in cancer

Fig. 3: Mitochondria OXPHOS pathway and TCA cycle participate in the ferroptosis.The alternative text for this image may have been generated using AI.

AMPK is the energy sensor, cancer cells with high basal AMPK activation are resistant to ferroptosis and AMPK inactivation sensitizes these cells to ferroptosis. Mechanistically, AMPK regulates ferroptosis through acetyl-CoA carboxylase (ACC) and polyunsaturated fatty acid (PUFA) biosynthesis. TCA metabolites such as α-KG and its downstream products succinic acid and fumaric acid could all enhance the ferroptosis induced by cysteine depletion.

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