Fig. 5: Vemurafenib alleviates LPS/z-VAD-induced macrophage necroptosis in mice.
From: Vemurafenib inhibits necroptosis in normal and pathological conditions as a RIPK1 antagonist
A Scheme of the murine model of macrophage necroptosis. B, C Representative flow cytometry plots and quantification showing the proportion of macrophages (CD11b+F4/80+) in the peritoneal cavity. n = 10 per group. The levels of proinflammatory cytokines in the peritoneal cavity (D) and serum (E) were determined by ELISA. n = 5 per group. P value was calculated by unpaired Student’s t-test. (*p < 0.05, **p < 0.01, ***p < 0.001).
