Fig. 3: Therapeutic approaches for liver regeneration.

Approaches targeting hepatic macrophages are shown. Metabolic reprogramming can be used to establish inflammation-resolving macrophages by reprogramming cells to undergo oxidative mitochondrial metabolism not proinflammatory glycolysis (left panel). An alternative strategy for boosting liver regeneration is macrophage-based cell therapy, which is being actively explored (right panel). See main text for details.