Fig. 1: PHF23 is expressed in lung cancer and associated with poor prognosis. | Cell Death & Disease

Fig. 1: PHF23 is expressed in lung cancer and associated with poor prognosis.

From: PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway

Fig. 1

A PHF23 mRNA expression was investigated in the TCGA database and compared among 33 kinds of tumors. B Analysis of the expression of PHF23 mRNA in NSCLC datasets from the GEO database. C Western blotting analyses of PHF23 levels in eight lung cancer tissues and matched normal tissues. N normal tissue, T tumor tissue. D Western blotting analyses of PHF23 expression in lung epithelial cell line, HBE, and six NSCLC cell lines. Error bars represent the mean ± SD from three independent experiments. P values are calculated by a two-tailed, unpaired t test. *P < 0.05; *P < 0.01; ***P < 0.001. E Immunofluorescence was performed to detect PHF23 localization in H1299 and A549 cell lines. F PHF23 levels in normal bronchial epithelial cells (I) and alveolar (II), adenocarcinoma (III), and squamous cell carcinoma (IV) using immunohistochemistry. Magnification: ×200. G Kaplan–Meier analysis of overall survival in all NSCLC patients.

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